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Identification of FBLL1 as a neuron-specific RNA 2'-O-methyltransferase mediating neuronal differentiation

Proc Natl Acad Sci U S A. 2024-11; 
Deyu Zhang , Bo Li , Henan Xu , Jingying Li , Chao Ma , Wei Ge , Congcong Lu , and Xuetao Cao
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摘要

2'-O-methylation is one of the most prevalent RNA modifications found in different RNA types. However, the identities of enzymes participating in the transfer of methyl groups are not well defined. To date, fibrillarin (FBL) is the only known small nucleolar ribonucleoprotein (snoRNP) 2'-O-methyltransferase. Whether other snoRNP 2'-O-methyltransferases exist and their functions in targeting RNAs to determine cell differentiation and function need to be elucidated. Here, we identify FBL-like protein 1 (FBLL1) as a 2'-O-methyltransferase and find its function in promoting neuronal differentiation. We show that FBLL1 is a key snoRNP complex enzyme that transfers methyl groups to substrate RNAs both in vitro and in... More

關鍵詞

2′-O-methylation; RNA methyltransferase; RNA modification; fibrillarin like protein 1; neuronal differentiation.
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