產品列表

產品應用

• 藥代動力學（Pharmacokinetics，PK）研究：用于檢測樣本中的抗體藥濃度

  金斯瑞的抗獨特型抗體適用于 PK 研究中的多種應用形式。

  

  金斯瑞提供兩種不同類型的用于PK研究的單克隆抗獨特型抗體。分別可以檢測游離藥物或總藥物水平。

  類型	抗原阻斷型	抗原非阻斷型
  示意圖
  特征	互補位特異	互補位非特異
  抗原結合	抑制	非抑制
  應用	檢測游離型抗體藥	檢測抗體藥總量（游離型和結合型）

• 免疫原性（Immunogenicity）研究：用作抗藥物抗體（anti-drug antibody，ADA）檢測的陽性對照

  金斯瑞的抗獨特型抗體適用于 ADA 研究中的多種應用形式。

  

產品性能

• 高親和力

  BLI (Biolayer interferometry) binding affinity measurements of MonoRab? Anti-Evolocumab Antibody (39B8), mAb, Rabbit (GenScript, A02293) to Evolocumab.Evolocumab captured on HFC (Anti-Human IgG Fc) Probes can bind MonoRab? Anti-Evolocumab Antibody (39B8), mAb, Rabbit with a dissociation constant (KD) of less than 1 pM.

  
• 高特異性

  Specificity analysis of the detection of Ocrelizumab.
  Ocrelizumab samples at 5 concentrations were spiked with 10 μg/mL of Rituximab. The test result demonstrated that the high concentration of Rituximab did not interfere with the detection of Ocrelizumab.
  In this ELISA assay, MonoRab? Anti-Ocrelizumab Antibody (12G10), mAb, Rabbit (GenScript, A02258) was coated at a concentration of 1 μg/mL, and MonoRab? Anti-Ocrelizumab Antibody (15E7), mAb, Rabbit (GenScript, A02259) conjugated with Biotin was used as a detection antibody at a concentration of 0.5 μg/mL.

  

  ELISA binding of Anti-Trastuzumab Antibody (11C4), mAb, Mouse (GenScript, A02032-40) with Trastuzumab and Pertuzumab. It shows the antibody does not recognize Pertuzumab.
  Coating antigen: Pertuzumab 1 μg/ml. Trastuzumab 1 μg/ml.
  Anti-Trastuzumab Antibody (11C4), mAb, Mouse (GenScript, A02032-40) dilution start from 1,000 ng/ml.

  
• 高專屬性

  MRD Analysis of the Detection of Lecanemab in Biological Matrix.
  The MRD is the minimum dilution necessary for the detection of Lecanemab in biological matrix with least interference. Serum samples from cynomolgus monkey were serially diluted to determine the MRD of this assay, and the test result suggested that MRD was as 1:10.
  In this ELISA assay, MonoRab? Anti-Lecanemab Antibody (44G1), mAb, Rabbit (GenScript, A02270) was coated at a concentration of 1 μg/ml, and MonoRab? Anti-Lecanemab Antibody (4F2), mAb, Rabbit (GenScript, A02271) conjugated with Biotin was used as a detection antibody at a concentration of 0.5 μg/mL.

  
• 多種應用模式

  Standard Curve of Lecanemab Sandwich ELISA by Anti-Lecanemab idiotype antibody 44G1 and 4F2.
  In this Sandwich ELISA assay, MonoRab? Anti-Lecanemab Antibody (44G1), mAb, Rabbit (GenScript, A02270) was coated at a concentration of 1 μg/ml, and MonoRab? Anti-Lecanemab Antibody (4F2), mAb, Rabbit (GenScript, A02271) conjugated with Biotin was used as a detection antibody at a concentration of 0.5 μg/mL. GenScript can provide customized conjugation service for this product per customer's request.
  In this assay, a four-parameter logistic curve fitting program was used to create a standard curve with the R-Square equal to 0.99971. The typicaldynamic range of the assay is 0.31 - 20 ng/mL and its detection limit is 0.31 ng/mL.

  

  Standard curve of the detection of Abatacept by Anti-Abatacept Antibody (CT.E8) and anti-human IgG Fc antibody.
  In the ELISA assay shown in this chart, Anti-Abatacept Antibody (CT.E8), mAb, Mouse (GenScript, A02263) was coated at a concentration of 1 μg/ml, and Mouse Anti-Human IgG Fc Antibody (50B4A9)[HRP], mAb (GenScript, A01854) was used as a detection antibody at a dilution of 1:2000.
  In this assay, a four-parameter logistic curve fitting program was used to create a standard curve with the R-Square is greater than 0.99. The typicaldynamic range of the assay is 4.69-300 ng/mL and its sensitivity of detecting Abatacept is up to 4.69 ng/mL.

  

  Standard curve and specificity analysis of the detection of Certolizumab pegol by Anti-Certolizumab Antibody (12A3) and anti-PEG antibody.
  In the ELISA assay shown in this chart, THE? PEG Antibody, mAb, Mouse (GenScript, A01795) was coated at a concentration of 2 μg/mL, and MonoRab? Anti-Certolizumab Antibody (12A3), mAb, Rabbit (GenScript, A02269) conjugated with Biotin was used as a detection antibody at a concentration of 0.5 μg/mL.In this assay, a four-parameter logistic curve fitting program was used to create a standard curve with the R-Square is greater than 0.999. The typicaldynamic range of the assay is 0.55-400 ng/mL and its sensitivity of detecting Certolizumab pegol is up to 0.55 ng/mL.

  
• 多種抗體類型

  Anti-Zolbetuximab Antibody (34E11) or (9C9) inhibits the binding of Zolbetuximab to Claudin18.2 (CLDN18.2).
  Anti-Zolbetuximab Antibody (34E11), mAb, Mouse (GenScript, A02260) exhibited non-inhibitory properties, whereas Anti-Zolbetuximab Antibody (9C9), mAb, Mouse (GenScript, A02261) demonstrated significant inhibitory properties with an IC₅₀ value of 0.44 μg/mL.

  
• 適用于ADC、雙抗等不同結構類型的分析物

  Standard curve of the detection of Trastuzumab deruxtecan (DS-8201) by Anti-Trastuzumab Antibody (15H2) and DXd Antibody (39F4)
  In this ELISA assay, Anti-Trastuzumab Antibody (11C4), mAb, Mouse (GenScript, A02032) was coated at a concentration of 2 μg/mL, and DXd Antibody (39F4), mAb, Mouse (GenScript, A02217) conjugated with HRP was used as a detection antibody at a concentration of 0.22 μg/mL.
  In this assay, a four-parameter logistic curve fitting program was used to create a standard curve with the R-Square is greater than 0.99. The typicaldynamic range of the assay is 1.56 - 100 ng/mL and its sensitivity of detecting Trastuzumab deruxtecan (DS-8201) is up to 1.56 ng/mL.

  

產品資料

抗獨特型抗體 抗獨特型抗體

助力抗體藥藥代動力學和免疫原性研究

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