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A 3D spheroid model of quadruple cell co-culture with improved liver functions for hepatotoxicity prediction

Toxicology. 2024-05; 
Baiyang Sun, Zihe Liang, Yupeng Wang, Yue Yu, Xiaobing Zhou, Xingchao Geng, Bo Li
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摘要

Drug-induced liver injury (DILI) is one of the major concerns during drug development. Wide acceptance of the 3?R principles and the innovation of in-vitro techniques have introduced various novel model options, among which the three-dimensional (3D) cell spheroid cultures have shown a promising prospect in DILI prediction. The present study developed a 3D quadruple cell co-culture liver spheroid model for DILI prediction via self-assembly. Induction by phorbol 12-myristate 13-acetate at the concentration of 15.42?ng/mL for 48?hours with a following 24-hour rest period was used for THP-1 cell differentiation, resulting in credible macrophagic phenotypes. HepG2 cells, PUMC-HUVEC-T1 cells, THP-1-originated ... More

關鍵詞

Drug-induced liver injury, In-vitro model, Margin of safety, Three-dimensional spheroids, Toxicity prediction
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