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CRTAC1 identified as a promising diagnosis and prognostic biomarker in lung adenocarcinoma

Sci Rep. 2024-05; 
Lin Tan, Han Zhang, Yun Ding, Yangyun Huang, Daqiang Sun
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Proteins, Expression, Isolation and Analysis … (SDS-PAGE) system (GenScript, Nanjing, China) and … selected 78 genes from the turquoise module as hub genes (|… genes, we ultimately identified CRTAC1 as the hub gene (Fig… Get A Quote

摘要

CRTAC1, one of the pyroptosis-related genes, has been identified as a protective factor in certain kinds of cancer, such as gastric adenocarcinoma and bladder cancer. The study aimed to investigate the role of CRTAC1 in lung adenocarcinoma (LUAD). LUAD datasets were obtained from Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA), pyroptosis-related genes from GeneCard. Limma package used to find differentially expressed genes (DEGs), least absolute shrinkage and selection operator (LASSO) regression and weighted genes co-expression network analysis (WGCNA) to identify CRTAC1 as hub gene. CRTAC1 expression was confirmed in a real-world cohort using quantitative polymerase chain reaction (... More

關鍵詞

CRTAC1, Diagnosis, LUAD, Prognosis, Pyroptosis
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