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Blue light-mediated gene expression as a promising strategy to reduce antibiotic resistance in Escherichia coli

Biotechnol J. 2024-05; 
Qingwei Jiang, Feng Geng, Juan Shen, Ping Zhu, Zhaoxin Lu, Fengxia Lu, Libang Zhou
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Proteins, Expression, Isolation and Analysis … [ 23 ] Update, the LOV proteins have been investigated in … to take advantage of LOV protein as optogenetic element to … in Table S2 were purchased from Genscript (Nanjing, China). DNA … Get A Quote

摘要

The discovery of antibiotics has noticeably promoted the development of human civilization; however, antibiotic resistance in bacteria caused by abusing and overusing greatly challenges human health and food safety. Considering the worsening situation, it is an urgent demand to develop emerging nontraditional technologies or methods to address this issue. With the expanding of synthetic biology, optogenetics exhibits a tempting prospect for precisely regulating gene expression in many fields. Consequently, it is attractive to employ optogenetics to reduce the risk of antibiotic resistance. Here, a blue light-controllable gene expression system was established in Escherichia coli based on a photosensitive DNA-bi... More

關鍵詞

EL222, Escherichia coli, antibiotic resistance, blue light, gene expression, optogenetics
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