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Hypoxic papillary thyroid carcinoma cells-secreted exosomes deliver miR-221-3p to normoxic tumor cells to elicit a pro-tumoral effect by regulating the ZFAND5

Exp Cell Res. 2023-07; 
Fan Yu, Xianzhao Deng, Yong Zhong, Bomin Guo, Xiaoping Zhang, Bo Wu
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Proteins, Expression, Isolation and Analysis … OE-ZFAND5) and empty pcDNA3.1 plasmid were synthesized and obtained from GenScript. … Sections were incubated with monoclonal antibodies against Ki-67 (ab15580; 1:200, Abcam… Get A Quote

摘要

Papillary thyroid cancer (PTC) has seen a worldwide expansion in incidence in the past three decades. Tumor-derived exosomes have been associated with the metastasis of cancer cells and are present within the local hypoxic tumor microenvironment, where they mediate intercellular communication by transferring molecules including microRNAs (miRNAs) between cells. Although miRNAs have been shown to serve as non-invasive biomarkers for cancer diagnosis, the role of hypoxia-induced tumor-derived exosomes in PTC progression remains unclear. Herein, we investigated the differentially expressed miRNA expression profiles from GEO datasets (GSE191117 and GSE151180) by using the DESeq package in R and identified a novel r... More

關(guān)鍵詞

Exosome, Hypoxic, Papillary thyroid carcinoma (PTC), ZFAND5, miR-221-3p
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