国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

Elife. 2021-01; 
Mark C Johnson, Geylani Can, Miguel Monteiro Santos, Diana Alexander, Philip Zegerman
Products/Services Used Details Operation
Recombinant Proteins Alpha-factor(GenScript Get A Quote

摘要

Checkpoints maintain the order of cell cycle events during DNA damage or incomplete replication. How the checkpoint response is tailored to different phases of the cell cycle remains poorly understood. The S-phase checkpoint for example results in the slowing of replication, which in budding yeast occurs by Rad53-dependent inhibition of the initiation factors Sld3 and Dbf4. Despite this, we show here that Rad53 phosphorylates both of these substrates throughout the cell cycle at the same sites as in S-phase, suggesting roles for this pathway beyond S-phase. Indeed, we show that Rad53-dependent inhibition of Sld3 and Dbf4 limits re-replication in G2/M, preventing gene amplification. In addition, we show that inh... More

關鍵詞

Rad53, S-phase, S. cerevisiae, cell cycle, checkpoints, chromosomes, gene expression, genome stability, replication
              主站蜘蛛池模板: 兖州市| 新宾| 威宁| 临湘市| 云林县| 秀山| 迁安市| 麟游县| 曲阳县| 和田市| 临夏市| 保靖县| 平南县| 赣榆县| 临邑县| 怀安县| 喀什市| 南宫市| 岳普湖县| 文成县| 尼玛县| 共和县| 余干县| 巴彦县| 海伦市| 运城市| 聊城市| 康平县| 肥东县| 利津县| 肇源县| 南阳市| 西城区| 兴安盟| 堆龙德庆县| 恩施市| 宾川县| 诏安县| 罗源县| 无极县| 伊金霍洛旗|