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LncRNA LEMD1-AS1 relieves chondrocyte inflammation by targeting miR-944/PGAP1 in osteoarthritis

Cell Cycle. 2022-06; 
Haitao Li, Kaihua Lian, Jianguang Mao, Fuguo Huang, Chunli Zhang, Jianguo Zang
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Proteins, Expression, Isolation and Analysis … Total protein from chondrocytes was isolated by RIPA buffer (Invitrogen, Carlsbad, CA, USA), and protein concentration was examined by BCA kit (GenScript, Nanjing, China). After … Get A Quote

摘要

Osteoarthritis (OA) is a common degenerative disease characterized by reducing articular chondrocytes and destruction of joint matrix, it's detailed pathogenesis remains unclear. Emerging evidences have demonstrated that long non-coding RNAs (lncRNAs) are closely related to the progression of OA. This study aims to explore the expression of long non-coding RNA LEMD1 antisense RNA 1 (LEMD1-AS1) in OA tissues and chondrocytes and investigate the possible mechanisms of LEMD1-AS1 in OA, which will provide a new target for the treatment of OA. In our study, LEMD1-AS1 and post-GPI attachment to protein (PGAP1) were lowly expressed, but miR-944 was highly expressed both in OA tissues and in Lipopolysaccharide (LPS) -t... More

關(guān)鍵詞

LEMD1-AS1, Osteoarthritis, PGAP1, chondrocyte, miR-944
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