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Human menstrual blood-derived stem cell transplantation suppresses liver injury in DDC-induced chronic cholestasis

Stem Cell Res Ther. 2022-02; 
Ya Yang, Yanfei Chen, Yalei Zhao, Feiyang Ji, Lingjian Zhang, Shima Tang, Sainan Zhang, Qingqing Hu, Zuhong Li, Fen Zhang, Qian Li, Lanjuan Li
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Proteins, Expression, Isolation and Analysis Equal amounts of total protein were transferred onto polyvinylidene fluoride (PVDF) membranes (Millipore, Bedford, MA, USA) after separation on 4–20% SDS–polyacrylamide electrophoresis gels (GenScript, Nanjing, China) Get A Quote

摘要

background: Cholestatic liver injury can lead to serious symptoms and prognoses in the clinic. Currently, an effective medical treatment is not available for cholestatic liver injury. Human menstrual blood-derived stem cells (MenSCs) are considered as an emerging treatment in various diseases. This study aimed to explore the treatment effect of MenSCs in cholestatic liver injury. methods: The treatment effect of MenSCs on chronic cholestatic liver injury was verified in 3,5-diethoxycarbonyl-1,4-dihydroxychollidine (DDC)-induced C57/BL6 mice. Pathological, fibrosis area in the liver tissue and serum liver enzymes were tested. Proteomics and western blot were used to explore the related targets and molecular mech... More

關(guān)鍵詞

Bile transporter, Chronic cholestatic liver injury, Mesenchymal stem cell, Tight junction
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