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The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders

Clin Transl Immunology. 2021-02; 
Wai Chin Chong, Madhur D Shastri, Gregory M Peterson, Rahul P Patel, Prabuddha S Pathinayake, Kamal Dua, Nicole G Hansbro, Alan C Hsu, Peter A Wark, Shakti Dhar Shukla, Matt D Johansen, Kate Schroder, Philip M Hansbro
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Recombinant Proteins … Sigma, St. Louis, USA), 10 ng/ml FGF2, 10 ng/ml vascular endothelial growth factor (GenScript, NJ, USA), 10 ng/ml epithelial growth factor (GenScript, NJ, USA), 10 ng/ml insulin-like growth factor (GenScript, NJ, USA). Cells?… Get A Quote

摘要

Inflammation is the result of a complex network of cellular and molecular interactions and mechanisms that facilitate immune protection against intrinsic and extrinsic stimuli, particularly pathogens, to maintain homeostasis and promote tissue healing. However, dysregulation in the immune system elicits excess/abnormal inflammation resulting in unintended tissue damage and causes major inflammatory diseases including asthma, chronic obstructive pulmonary disease, atherosclerosis, inflammatory bowel diseases, sarcoidosis and rheumatoid arthritis. It is now widely accepted that both endoplasmic reticulum (ER) stress and inflammasomes play critical roles in activating inflammatory signalling cascades. Notably, evi... More

關鍵詞

NLRP3, endoplasmic reticulum stress, inflammasome, inflammatory disorder
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