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Xeno-Nucleic Acid (XNA) 2'-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding

Viruses. 2021-10; 
Irani Alves Ferreira-Bravo, Jeffrey J DeStefano
Products/Services Used Details Operation
Proteins, Expression, Isolation and Analysis … Neutralizing RBD antibody (GenScript 6D11F2) was compared with FANA-R8–9 and FANA-ST (starting material) in an ACE2 ELISA assay (GenScript). * Percent inhibition was calculated based on positive and negative controls supplied by the manufacturer. The negative … Get A Quote

摘要

The causative agent of COVID-19, SARS-CoV-2, gains access to cells through interactions of the receptor-binding domain (RBD) on the viral S protein with angiotensin-converting enzyme 2 (ACE2) on the surface of human host cells. Systematic evolution of ligands by exponential enrichment (SELEX) was used to generate aptamers (nucleic acids selected for high binding affinity to a target) to the RBD made from 2'-fluoro-arabinonucleic acid (FANA). The best selected ~79 nucleotide aptamers bound the RBD (Arg319-Phe541) and the larger S1 domain (Val16-Arg685) of the 1272 amino acid S protein with equilibrium dissociation constants () of ~10-20 nM, and binding half-life for the RBD, S1 domain, and full trimeric S protei... More

關鍵詞

ACE2, FANA, SARS-CoV-2 RBD, XNA, aptamer
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