γ-glutamyl peptides have been suggested to impart properties to foods by activating human calcium-sensing receptor (hCaSR). In this study, the relationship between γ-glutamyl peptide structure and hCaSR activity was systematically analyzed using γ-[Glu]-α-[Glu]-Tyr. Our results suggest that N-terminal [Glu] moiety is very important for hCaSR activities of γ-glutamyl peptides.

kokumi, calcium-sensing receptor, gamma-glutamyl peptide, structure-activity relationship study