Products/Services Used | Details | Operation |
---|---|---|
Proteins, Expression, Isolation and Analysis> | To characterise its epitope, the TMEM106B C-terminal fragment (120-274) incorporated into pET3A was purchased from Genscript. | Get A Quote |
Filaments made of residues 120-254 of transmembrane protein 106B (TMEM106B) form in an age-dependent manner and can be extracted from the brains of neurologically normal individuals and those of subjects with a variety of neurodegenerative diseases. TMEM106B filament formation requires cleavage at residue 120 of the 274 amino acid protein; at present, it is not known if residues 255-274 form the fuzzy coat of TMEM106B filaments. Here we show that a second cleavage appears likely, based on staining with an antibody raised against residues 263-274 of TMEM106B. We also show that besides the brain TMEM106B inclusions form in dorsal root ganglia and spinal cord, where they were mostly found in non-neuronal cells. We... More
喜歡新升級的網站嗎?
討厭
不喜歡
一般
喜歡
非常喜歡
*如果您想收到后續信息,請輸入您的電子郵件地址