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Tumor vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA): Suppresses macrophage capping protein beyond STING activation

Biochim Biophys Acta Mol Basis Dis. 2024-04; 
Zhiyong Xiao, Xia Cui, Feng Liu, Ying Wang, Xiao Liu, Wenxia Zhou, Yongxiang Zhang
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Proteins, Expression, Isolation and Analysis … (Genscript, Hong Kong, China) and probed for macrophage capping protein (CapG) (Proteintech, Chicago, USA). GAPDH (Applygen, Beijing, China) was used as an internal control. … Get A Quote

摘要

The vascular disrupting agent (VDA) 5,6-dimethylxanthenone-4-acetic acid (DMXAA) induces apoptosis in vascular endothelial cells and leads to tumor hemorrhagic necrosis. While DMXAA has been proven to be a potent agonist of murine stimulator of interferon genes (mSTING), it has little effect on human-STING (hSTING). This species selectivity of DMXAA may explain its effectiveness against solid tumors in mice and its failure in clinical trials. However, DMXAA did reduce tumor volume in some patients during clinical trials. These paradoxical results have prompted us to investigate the anti-tumor mechanism of DMXAA beyond STING in the destruction of tumor vasculature in humans. In this study, we demonstrated that D... More

關鍵詞

DMXAA, Macrophage capping protein, Stimulator of interferon genes, Vascular destruction
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