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Critical Aggregation Concentration Can be a Predictor of Doxorubicin Delivery Performance of Self-Assembling Amphiphilic Peptides with Different Hydrophobic Tails

J Pharm Sci. 2024-02; 
Saeed Zanganeh, Loghman Firoozpour, Maryam Samareh Salavatipour, Soroush Sardari, Reza Ahangari Cohan, Nasir Mohajel
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Proteins, Expression, Isolation and Analysis … (Genscript, NJ, USA), and the N-terminus 6 × histidine-tagged chimeric proteins were … Protein purification was performed by affinity chromatography using a HisTrap crude FF (GE)… Get A Quote

摘要

Amphiphilic peptides hold great potential as drug delivery systems. A popular peptide design approach has been to place amino acids in the peptide sequence based on their known properties. On the other hand, the directed discovery approach aims to screen a sequence space for a desired property. However, screening amphiphilic peptides for desirable drug delivery properties is not possible without a quantity that is predictive of these properties. We studied the predictive power of critical aggregation concentration (CAC) values on the drug delivery performance of a series of amphiphilic peptides with different hydrophobic tails and close CAC values. The CAC values were predicted by our previously developed model... More

關鍵詞

Biomaterial, Cancer chemotherapy, Drug delivery system, Encapsulation, Machine learning, Nanoparticle, Peptide, Peptide delivery, QSPR, Surfactant
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