国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

Caveolin-3 negatively regulates endocytic recycling of cardiac K channels

Am J Physiol Cell Physiol. 2023-09; 
Jian-Yi Huo, Yu-Long Feng, Yue-Tong Chen, Bo Yang, Ya-Ting Zhi, Hao-Jie Wang, Hua-Qian Yang
Products/Services Used Details Operation
Gene Synthesis … 4HA/6myc, Flag-SUR2A-Cav3-FL- 91 6myc/4HA/KEHR-A/3C-S, and Flag-SUR2A-Cav3-MAD1-KEHR-A/3C-S, were generated by GenBuilder 92 (L00701 Genscript) Gibson cloning … Get A Quote

摘要

Sarcolemmal ATP-sensitive potassium (K) channels play a vital role in cardioprotection. Cardiac K channels are enriched in caveolae and physically interact with the caveolae structural protein caveolin-3 (Cav3). Disrupting caveolae impairs the regulation of K channels through several signaling pathways. However, the direct functional effect of Cav3 on K channels is still poorly understood. Here, we used the cardiac K channel subtype, Kir6.2/SUR2A, and showed that Cav3 greatly reduced K channel surface density and current amplitude in a caveolae-independent manner. A screen of Cav3 functional domains revealed that a 25 amino acid region in the membrane attachment domain of Cav3 is the minimal effective segment (... More

關鍵詞

Caveolin-3, KATP channel, Rab11A, cardioprotection, surface density
              主站蜘蛛池模板: 华容县| 石嘴山市| 高要市| 舟曲县| 奉贤区| 长治县| 龙岩市| 蓬溪县| 沭阳县| 巴彦淖尔市| 沙坪坝区| 卫辉市| 剑河县| 高唐县| 萍乡市| 保靖县| 会理县| 志丹县| 仁布县| 色达县| 大理市| 谢通门县| 上蔡县| 阜城县| 九江县| 吴川市| 湄潭县| 宁都县| 呼和浩特市| 克拉玛依市| 乐亭县| 玛多县| 安国市| 科技| 那曲县| 准格尔旗| 凌海市| 肇庆市| 安乡县| 大田县| 阿拉善右旗|