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Inefficient recruitment of DDX39B impedes pre-spliceosome assembly on introns

RNA. 2024-06; 
Chloe K Nagasawa, Aaron O Bailey, William K Russell, Mariano A Garcia-Blanco
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Proteins, Expression, Isolation and Analysis … protein concentration was quantified by BCA (Thermo Fisher Scientific). For western blot analysis, 15 μg of total protein prepared in 1× LDS sample buffer (GenScript) … gels (GenScript), … Get A Quote

摘要

Forkhead box P3 (FOXP3) is the master fate-determining transcription factor in regulatory T (T) cells and is essential for their development, function, and homeostasis. Mutations in cause immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome, and aberrant expression of has been implicated in other diseases such as multiple sclerosis and cancer. We previously demonstrated that pre-mRNA splicing of RNAs is highly sensitive to levels of DExD-box polypeptide 39B (DDX39B), and here we investigate the mechanism of this sensitivity. introns have cytidine (C)-rich/uridine (U)-poor polypyrimidine (py) tracts that are responsible for their inefficient splicing and confer sensitivity to DDX39B. W... More

關鍵詞

DDX39B, FOXP3, IPEX syndrome, autoimmunity, multiple sclerosis, pre-mRNA splicing
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