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DAB2IP-knocking down resulted in radio-resistance of breast cancer cells is associated with increased hypoxia and vasculogenic mimicry formation

Int J Radiat Biol. 2023-03; 
Xiangyan Zhang, Quanxin Wang, Ruiqi Zhang, Zhaolu Kong
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Proteins, Expression, Isolation and Analysis … The primers sequences of each gene were purchased by GenScript (Nanjing, Jiangsu, China), and listed in Supplementary Table 1. Each sample was performed in duplicates. … Get A Quote

摘要

purpose: As a part of breast-conserving therapy (BCT), postoperative radiotherapy is one of the main means to improve the clinical efficacy of breast cancer (BCa). However, ionizing radiation (IR) may induce BCa cells to develop radioresistance, which causes tumor recurrence and metastasis after treatment. Recently, DOC-2/DAB2 interactive protein (DAB2IP) has been reported often down-regulated in a variety of cancers and is related to tumor tolerance to radiotherapy. In this study, BCa cell lines were introduced to study how DAB2IP deficient influenced BCa cell radiosensitivity and and discuss the possible mechanism. methods and materials: Small RNA interference system (siRNA) was employed to decrease DAB2IP ... More

關鍵詞

Breast cancer, DAB2IP, angiogenesis, hypoxia, radiosensitivity
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