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Neuroprotective Effects of N-methyl-(2S, 4R)-trans-4-hydroxy-L-proline (NMP) against Amyloid-β-Induced Alzheimer's Disease Mouse Model

Nutrients. 2023-12; 
Jawad Ali, Amjad Khan, Jun Sung Park, Muhammad Tahir, Waqas Ahmad, Kyonghwan Choe, Myeong Ok Kim
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Peptide Synthesis … , (Dallas, TX, USA), while amyloid beta peptide (Aβ 1–42, catalog number RP10017) was purchased from GenScript. The primary antibodies used in the study are shown in Table 1. … Get A Quote

摘要

Alzheimer's disease (AD), is a progressive neurodegenerative disorder that involves the deposition of β-amyloid plaques and the clinical symptoms of confusion, memory loss, and cognitive dysfunction. Despite enormous progress in the field, no curative treatment is available. Therefore, the current study was designed to determine the neuroprotective effects of N-methyl-(2S, 4R)-Trans-4-hydroxy-L-proline (NMP) obtained from Sideroxylon obtusifolium, a Brazilian folk medicine with anti-inflammatory and anti-oxidative properties. Here, for the first time, we explored the neuroprotective role of NMP in the Aβ-injected mouse model of AD. After acclimatization, a single intracerebroventricular injection of Aβ (5 μ... More

關鍵詞

Alzheimer’s disease, N-methyl-(2S, 4R)-Trans-4-hydroxy-L-proline (NMP), amyloid beta (Aβ1–42), neuroinflammation, neuroprotection, oxidative stress
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