国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells

Nat Commun. 2024-01; 
Seungwon Jung , Seung Hwan Ko , Narae Ahn , Jinsam Lee , Chang-Hwan Park , Jungwook Hwang
Products/Services Used Details Operation
Polyclonal Antibody Services … during early differentiation of pluripotent stem cells | Nature Communications … 2.nature communications … the following primary antibodies: anti-FLAG (GenScript, A00187; 1:2000), UPF1 (… Get A Quote

摘要

UPF1 and LIN28A are RNA-binding proteins involved in post-transcriptional regulation and stem cell differentiation. Most studies on UPF1 and LIN28A have focused on the molecular mechanisms of differentiated cells and stem cell differentiation, respectively. We reveal that LIN28A directly interacts with UPF1 before UPF1-UPF2 complexing, thereby reducing UPF1 phosphorylation and inhibiting nonsense-mediated mRNA decay (NMD). We identify the interacting domains of UPF1 and LIN28A; moreover, we develop a peptide that impairs UPF1-LIN28A interaction and augments NMD efficiency. Transcriptome analysis of human pluripotent stem cells (hPSCs) confirms that the levels of NMD targets are significantly regulated by both U... More

關鍵詞

              主站蜘蛛池模板: 临澧县| 原阳县| 寿宁县| 体育| 昆山市| 巩留县| 巴青县| 温州市| 太和县| 东平县| 常宁市| 旌德县| 墨脱县| 徐州市| 达孜县| 淮南市| 铁力市| 苏尼特右旗| 汉阴县| 武清区| 宿松县| 定边县| 海门市| 宝山区| 奉新县| 时尚| 梁河县| 蒙自县| 建宁县| 民县| 彭山县| 青龙| 抚松县| 芦溪县| 黎城县| 龙井市| 科技| 福泉市| 河间市| 石林| 边坝县|