Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021
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… the ELISA cut-off is 0.5 optical density (OD) [2]. Samples were further tested using a surrogate
virus neutralisation test (sVNT) kit (GenScript, New Jersey, United States), which measures?… |
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The mRNA vaccine Comirnaty and the inactivated vaccine CoronaVac are both available in Hong Kong's COVID-19 vaccination programme. We observed waning antibody levels in 850 fully vaccinated (at least 14 days passed after second dose) blood donors using ELISA and surrogate virus neutralisation test. The Comirnaty-vaccinated group's (n?=?593) antibody levels remained over the ELISA and sVNT positive cut-offs within the first 6 months. The CoronaVac-vaccinated group's (n?=?257) median antibody levels began to fall below the cut-offs 4 months after vaccination.
The mRNA vaccine Comirnaty and the inactivated vaccine CoronaVac are both available in Hong Kong's COVID-19 vaccination programme. We observed waning antibody levels in 850 fully vaccinated (at least 14 days passed after second dose) blood donors using ELISA and surrogate virus neutralisation test. The Comirnaty-vaccinated group's (n?=?593) antibody levels remained over the ELISA and sVNT positive cut-offs within the first 6 months. The CoronaVac-vaccinated group's (n?=?257) median antibody levels began to fall below the cut-offs 4 months after vaccination.
BNT162b2, COVID-19, CoronaVac, SARS-CoV-2, antibody, vaccine
