国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務(wù)及產(chǎn)品已被Cell, Nature, Science, PNAS等1300多家生物醫(yī)藥類雜志引用近萬次,處于行業(yè)領(lǐng)先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學(xué)等約400家全球著名機(jī)構(gòu)使用GenScript的基因合成、多肽服務(wù)、抗體服務(wù)和蛋白服務(wù)等成功地發(fā)表科研成果,再次證明GenScript 有能力幫助業(yè)內(nèi)科學(xué)家Make research easy.

Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies

EMBO J. 2021-08; 
Thomas Güttler, Metin Aksu, Antje Dickmanns, Kim M Stegmann, Kathrin Gregor, Renate Rees, Waltraud Taxer, Oleh Rymarenko, Jürgen Schünemann, Christian Dienemann, Philip Gunkel, Bianka Mussil, Jens Krull, Ulrike Teichmann, Uwe Gro?, Volker C Cordes, Matthias Dobbelstein, Dirk G?rlich
Products/Services Used Details Operation
Recombinant Proteins biotinylated nanobodies were immobilized, incubated with 20, 6.66, and 2.22?nM RBD wt (Z03479, GenScript) Get A Quote

摘要

Monoclonal anti-SARS-CoV-2 immunoglobulins represent a treatment option for COVID-19. However, their production in mammalian cells is not scalable to meet the global demand. Single-domain (VHH) antibodies (also called nanobodies) provide an alternative suitable for microbial production. Using alpaca immune libraries against the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein, we isolated 45 infection-blocking VHH antibodies. These include nanobodies that can withstand 95°C. The most effective VHH antibody neutralizes SARS-CoV-2 at 17-50?pM concentration (0.2-0.7?μg per liter), binds the open and closed states of the Spike, and shows a tight RBD interaction in the X-ray and cryo-EM structures. ... More

關(guān)鍵詞

COVID-19, Coronaviridae, SARS-CoV-2, VHH antibody, nanobody
              主站蜘蛛池模板: 南靖县| 筠连县| 儋州市| 确山县| 天全县| 阿图什市| 红河县| 怀来县| 含山县| 克什克腾旗| 胶南市| 江门市| 宁波市| 清水县| 沂水县| 方城县| 婺源县| 阜城县| 婺源县| 宁安市| 松阳县| 津市市| 高碑店市| 梁山县| 岳阳县| 阜新市| 百色市| 丹巴县| 温泉县| 疏勒县| 德钦县| 成安县| 山东省| 佛冈县| 汝城县| 麻栗坡县| 施甸县| 当雄县| 无为县| 景东| 延寿县|