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Mt10-CVB3 Vaccine Virus Protects against CVB4 Infection by Inducing Cross-Reactive, Antigen-Specific Immune Responses

Microorganisms. 2021-11; 
Ninaad Lasrado, Rajkumar Arumugam, Mahima T Rasquinha, Meghna Sur, David Steffen, Jay Reddy
Products/Services Used Details Operation
Proteins, Expression, Isolation and Analysis Full-length CVB3 VP1 (GenScript, Piscataway, NJ, USA) and keyhole limpet hemocyanin (KLH) protein (Sigma-Aldrich, St. Louis, MO, USA) were procured commercially. Get A Quote

摘要

Group B coxsackieviruses (CVB) containing six serotypes, B1-B6, affect various organs, and multiple serotypes can induce similar diseases such as myocarditis and pancreatitis. Yet, no vaccines are currently available to prevent these infections. Translationally, the derivation of vaccines that offer protection against multiple serotypes is highly desired. In that direction, we recently reported the generation of an attenuated strain of CVB3, termed Mt10, which completely protects against both myocarditis and pancreatitis induced by the homologous wild-type CVB3 strain. Here, we report that the Mt10 vaccine can induce cross-protection against multiple CVB serotypes as demonstrated with CVB4. We note that the Mt1... More

關鍵詞

coxsackievirus B1, coxsackievirus B3, coxsackievirus B4, cross protection, pancreatitis, vaccine
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