国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

Engineered human antibodies for the opsonization and killing of

Proc Natl Acad Sci U S A. 2022-01; 
Xinhai Chen, Olaf Schneewind, Dominique Missiakas
Products/Services Used Details Operation
Proteins, Expression, Isolation and Analysis … to produce antibodies (35) were injected with 100 μg hIgG1 or … on protein G resin (GenScript) and dialyzed against PBS as … 2 and 3 mg/mL was injected in PBS pH 7.2 over the column. … Get A Quote

摘要

Gram-positive organisms with their thick envelope cannot be lysed by complement alone. Nonetheless, antibody-binding on the surface can recruit complement and mark these invaders for uptake and killing by phagocytes, a process known as opsonophagocytosis. The crystallizable fragment of immunoglobulins (Fcγ) is key for complement recruitment. The cell surface of is coated with Staphylococcal protein A (SpA). SpA captures the Fcγ domain of IgG and interferes with opsonization by anti- antibodies. In principle, the Fcγ domain of therapeutic antibodies could be engineered to avoid the inhibitory activity of SpA. However, the SpA-binding site on Fcγ overlaps with that of the neonatal Fc receptor (FcRn), an inte... More

關鍵詞

C1q, FcRn, Staphylococcus aureus, engineered antibody, immune evasion
              主站蜘蛛池模板: 红桥区| 亳州市| 江孜县| 武定县| 林州市| 儋州市| 滁州市| 崇仁县| 吴堡县| 广平县| 罗定市| 吴川市| 通道| 新和县| 巧家县| 清河县| 鞍山市| 吴旗县| 神农架林区| 巴楚县| 安国市| 玛多县| 威海市| 会昌县| 新津县| 永和县| 廊坊市| 锦屏县| 江安县| 永康市| 昌平区| 东方市| 思南县| 九龙城区| 清流县| 长沙县| 定州市| 文昌市| 策勒县| 梁山县| 安西县|