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Engineered human antibodies for the opsonization and killing of

Proc Natl Acad Sci U S A. 2022-01; 
Xinhai Chen, Olaf Schneewind, Dominique Missiakas
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Proteins, Expression, Isolation and Analysis … to produce antibodies (35) were injected with 100 μg hIgG1 or … on protein G resin (GenScript) and dialyzed against PBS as … 2 and 3 mg/mL was injected in PBS pH 7.2 over the column. … Get A Quote

摘要

Gram-positive organisms with their thick envelope cannot be lysed by complement alone. Nonetheless, antibody-binding on the surface can recruit complement and mark these invaders for uptake and killing by phagocytes, a process known as opsonophagocytosis. The crystallizable fragment of immunoglobulins (Fcγ) is key for complement recruitment. The cell surface of is coated with Staphylococcal protein A (SpA). SpA captures the Fcγ domain of IgG and interferes with opsonization by anti- antibodies. In principle, the Fcγ domain of therapeutic antibodies could be engineered to avoid the inhibitory activity of SpA. However, the SpA-binding site on Fcγ overlaps with that of the neonatal Fc receptor (FcRn), an inte... More

關鍵詞

C1q, FcRn, Staphylococcus aureus, engineered antibody, immune evasion
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