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Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Ad26CoV2S Vaccination in People Living With Human Immunodeficiency Virus (HIV)

Clin Infect Dis. 2022-08; 
Khadija Khan, Gila Lustig, Mallory Bernstein, Derseree Archary, Sandile Cele, Farina Karim, Muneerah Smith, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Yoliswa Miya, Ntombifuthi Mthabela, Nombulelo P Magula, Richard Lessells, Tulio de Oliveira, Bernadett I Gosnell, Salim Abdool Karim, Nigel Garrett, Willem Hanekom, Linda-Gail Bekker, Glenda Gray, Jonathan M Blackburn, Mahomed-Yunus S Moosa, Alex Sigal
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Monoclonal Antibody Services GenScript A02051 anti-spike neutralizing monoclonal antibody was added as a positive … Foci is stained with a rabbit anti-spike monoclonal antibody (BS-R2B12; GenScript A02058) at … Get A Quote

摘要

background: People living with HIV (PLWH) have been reported to have a higher risk of more severe COVID-19 disease and death. We assessed the ability of the Ad26.CoV2.S vaccine to elicit neutralizing activity against the Delta variant in PLWH relative to HIV-negative individuals. We also examined effects of HIV status and suppression on Delta neutralization response in SARS-CoV-2-infected unvaccinated participants. methods: We enrolled participants who were vaccinated through the SISONKE South African clinical trial of the Ad26.CoV2.S vaccine in healthcare workers (HCWs). PLWH in this group had well-controlled HIV infection. We also enrolled unvaccinated participants previously infected with SARS-CoV-2. Neutral... More

關鍵詞

Ad26.CoV2.S vaccines, HIV viremia, SARS-CoV-2, immunogenicity, neutralization
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