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GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sj?gren syndrome

Inflamm Res. 2022-10; 
Jie Tian, Beibei Zhang, Qingfang Yuan, Xueqing Sun, Na Peng, Bo Zhu, Chang Liu, Xiaoran Wang, Man Han, Meng Cao, Fan Xiao, Shengjun Wang, Ke Rui, Liwei Lu
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Proteins, Expression, Isolation and Analysis … Endotoxin was removed by Toxin Eraser endotoxin removal resin (GenScript) and detected by E-TOXATE Kits (Sigma-Aldrich). The endotoxin levels of both GITRL and control are less … Get A Quote

摘要

background: Recent studies have revealed a role of the ligand for glucocorticoid-induced TNFR family-related protein (GITRL) in mediating functional dysregulations of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of primary Sj?gren syndrome (pSS), but the underlying molecular mechanism is largely unclear. In this study, we aimed to elucidate GITRL-mediated signaling pathways in MDSCs during the development of experimental SS (ESS). methods: MDSCs were stimulated with recombinant GITRL, the activation of PTEN, AKT and STAT3 in MDSCs was analyzed by Western blot. MDSCs with different treatment were adoptively transferred to ESS mice. ELISA was used to detect the level of autoantibodies. Proportion... More

關鍵詞

Autoimmune disease, GITRL, MDSCs, PTEN, Sj?gren’s syndrome
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