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Trifluoro-icaritin ameliorates spared nerve injury-induced neuropathic pain by inhibiting microglial activation through α7nAChR-mediated blockade of BDNF/TrkB/KCC2 signaling in the spinal cord of rats

Biomed Pharmacother. 2022-11; 
Dandan Jia, Guangsen Liu, Yalan Sun, Zhiping Hu, Zhihua Huang, Cheng Huang
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Recombinant Proteins … BDNF (GenScript, China) was dissolved as a concentrated stock solution (0.5 μg/μl) in PBS. Isoflurane was purchased from Jiangsu hengfengqiang Biotechnology Co., Ltd. … Get A Quote

摘要

Neuropathic pain is still a serious and unsolved health problem. Activation of α7 nicotinic acetylcholine receptor (α7nAChR) is known to modulate neuropathic pain by inhibiting microglial activation and BDNF/TrkB/KCC2 signaling. We previously identified that trifluoro-icaritin (ICTF) has an attenuated effect on spared nerve injury (SNI)-induced neuropathic pain, but its potential mechanisms remain unknown. Here, the pain-related behaviors were determined by paw withdrawal threshold (PWT), CatWalk gait analysis, rotarod test, open field test and elevated plus maze test. The expression of pain-related signal molecules was evaluated by Western blot and immuno?uorescence staining. The results showed that ICTF (... More

關(guān)鍵詞

BDNF/TrkB/KCC2, Microglial activation, Neuropathic pain, Trifluoro-icaritin, α7nAChR
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