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Inhibition of EZH2 attenuates coronary heart disease by interacting with microRNA-22 to regulate the TXNIP/nuclear factor-κB pathway

Exp Physiol. 2020; 
Yong Liu, Chuanzhong Dai, Yuping Lei, Wenzhen Wu, Wen Liu
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Recombinant Proteins … added to the HUVEC medium and 20 μg/L human platelet derived growth factor-BB (PDGF-BB, GenScript, Piscataway, NJ, USA) was added to the VSMC medium to Page 6. This article is protected by copyright. All rights reserved. 6 incubate for 48 h to obtain CHD cells. 2.7?… Get A Quote

摘要

unassigned: What is the central question of this study? The relevance of microRNA-22 (miR-22) has been indicated in coronary heart disease (CHD). How does it exert a protective role in CHD? What is the main finding and its importance? EZH2 inhibited transcription of the miR-22 promoter, thus modulating cell proliferation in human umbilical vein endothelial cells and vascular smooth muscle cells to induce CHD. unassigned: MicroRNA-22 (miR-22) was indicated to modulate cell proliferation in human umbilical vein endothelial cells (HUVECs) under exposure to environmental toxicants. In the present study, we investigated the involvement of miR-22 in the mediation of HUVEC and vascular smooth muscle cell (VSMC) functi... More

關鍵詞

EZH2, TXNIP, coronary heart disease, microRNA-22, nuclear factor-κB
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