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Integrin α-3 ?-1's central role in breast cancer, melanoma and glioblastoma cell aggregation revealed by antibodies with blocking activity

MAbs. 2019; 
Daniel F. Lusche, Michael R. Klemme, Benjamin A. Soll, Ryan J. Reis, Cristopher C. Forrest, Tiffany S. Nop, Deborah J. Wessels, Brian Berger, Rebecca Glover & David R. Soll
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摘要

Breast cancer, melanoma and glioblastoma cells undergo cell-mediated aggregation and aggregate coalescence in a transparent 3D Matrigel environment. Cells from normal tissue and non-tumorigenic cell lines do not exhibit these behaviors. Here, 266 monoclonal antibodies (mAbs) demonstrated to interact with a wide variety of membrane, secreted and matrix proteins, have been screened for their capacity to block these tumorigenic cell-specific behaviors in a 3D environment. Remarkably, only six of the 266 tested mAbs exhibited blocking activity, four targeting integrin ?-1, one targeting integrin α-3 and one targeting CD44. Colocalization of integrins ?-1 and α-3 in fixed cells and in live aggregates suggests th... More

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