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hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells.

PLoS Genet. 2015; 
Thompson PJ, Dulberg V, Moon KM, Foster LJ, Chen C, Karimi MM, Lorincz MC.
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Catalog Antibody Ng reported previously [28]), anti-hnRNP K 3C2 (Abcam), anti-KAP1 20C1 (Abcam), anti-DYKDDDDK (FLAG, GenScript A00187–200), or rabbit or mouse IgG (Sigma-Aldrich I8140 and I8765).... Nuclear extracts were prepared as above with 10 mM NEM and immunoprecipitated overnight with anti- DYKDDDDK (FLAG) antibodies (GenScript). Get A Quote

摘要

Retrotransposition of endogenous retroviruses (ERVs) poses a substantial threat to genome stability. Transcriptional silencing of a subset of these parasitic elements in early mouse embryonic and germ cell development is dependent upon the lysine methyltransferase SETDB1, which deposits H3K9 trimethylation (H3K9me3) and the co-repressor KAP1, which binds SETDB1 when SUMOylated. Here we identified the transcription co-factor hnRNP K as a novel binding partner of the SETDB1/KAP1 complex in mouse embryonic stem cells (mESCs) and show that hnRNP K is required for ERV silencing. RNAi-mediated knockdown of hnRNP K led to depletion of H3K9me3 at ERVs, concomitant with de-repression of proviral reporter constructs and ... More

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