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Bone regeneration and mineralisation was promoted during distraction osteogenesis by human periostin gene in rabbit mandibular model.

J Stomatol Oral Maxillofac Surg. 2020; 
Jiang X, Chen J, Huang H, Chen Y, Peng H.
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Recombinant Proteins … synthase kinase-3β(p-GSK3β,1:500; Santa Cruz, USA), collagen 1(Col1,1:500; GenScript Bioteck, China), vascular endothelial growth factor(VEGF, 1:800; Abcam, Hong Kong), and runt-related transcription factor 2 (Runx2,1:500, Boster, China) expression … Get A Quote

摘要

To study the effect of periostin gene on bone regeneration and mineralisation during distraction osteogenesis (DO) in a rabbit mandibular model.,A total of 54 New Zealand white rabbits underwent mandibular lengthening and were divided into group A and group B (n=27, each). At the end of the distraction, adenoviruses containing human POSTN/enhanced green fluorescent protein (Ad5-POSTN/EGFP) viruses or Ad5-POSTN viruses were injected into the distraction gaps in the group B or A, respectively. On the 4th and 8th week after distraction, eight samples, randomly selected from each group, were subjected to CT scanning and dual energy X-ray absorptiometry detection. All animals from each group were sacrificed for micr... More

關鍵詞

Adenovirus; Distraction osteogensis; Mandibular; Periostin; Rabbit
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