国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

PARP1 Suppresses the Transcription of PD-L1 by Poly(ADP-Ribosyl)ating STAT3.

Cancer Immunol Res. 2019; 
DingLing,ChenXi,XuXiaqing,QianYuli,LiangGuikai,YaoFengqi,YaoZhangting,WuHonghai,ZhangJieqiong,HeQiaojun,Ya
Products/Services Used Details Operation
Catalog Antibody Anti-DYKDDDDK-tag (#A00187) and anti-DYKDDDDK IP resin (#L00425) were purchased from GenScript. Get A Quote

摘要

Studies have pointed to a role of PARP1 in regulating gene expression through poly(ADP-ribosyl)ating, sequence-specific, DNA-binding transcription factors. However, few examples exist that link this role of PARP1 to the immunogenicity of cancer cells. Here, we report that PARP1 poly(ADP-ribosyl)ates STAT3 and subsequently promotes STAT3 dephosphorylation, resulting in reduced transcriptional activity of STAT3 and expression of PD-L1. In this study, we showed that PARP1 silencing or pharmacologic inhibition enhanced the transcription of PD-L1 in cancer cells, which was accompanied by the upregulation of PD-L1 protein expression, both in the cytoplasm and on the cell surface. This induction of PD-... More

關鍵詞

              主站蜘蛛池模板: 卢湾区| 静海县| 师宗县| 衡阳县| 洛阳市| 云南省| 尚志市| 海安县| 财经| 丹寨县| 巴林右旗| 达尔| 宜兰市| 濮阳市| 巧家县| 兰州市| 达尔| 武城县| 滁州市| 宜都市| 绥滨县| 三都| 枣庄市| 滦平县| 灵寿县| 梁平县| 凭祥市| 德州市| 永平县| 三都| 新闻| 海门市| 阿拉善左旗| 宁国市| 承德县| 彩票| 房产| 乐东| 老河口市| 钟山县| 喀什市|