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Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome.

Microbiome. 2019-01;

SongZiwei，CaiYuanyuan，LaoXingzhen，WangXue，LinXiaoxuan，CuiYingyun，KalavaguntaPraveen Kumar，LiaoJun，JinLiang，ShangJing，Li

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Recombinant Proteins	CDCA-d4 (CAS: 99102-69-9), UDCA-d4 (CAS: 347841-46-7), glycine (CAS: 56-40-6), and taurine (CAS: 107-35-7) were used in the enzyme assay. pET28a (+) was used for the expression of His-tagged (6x) recombinant BSH (Genscript, Nanjing, China).	Get A Quote

摘要

Bile salt hydrolase plays an important role in bile acid-mediated signaling pathways， which regulate lipid absorption， glucose metabolism， and energy homeostasis. Several reports suggest that changes in the composition of bile acids are found in many diseases caused by dysbacteriosis.