MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice
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| Gene Synthesis |
… A polynucleotide encoding three copies of tau 2-18 epitope separated by GS linkers was
synthesized by GenScript (Piscataway, NJ) and subcloned in frame with the MultiTEP minigene
(amplified by PCR from AV-1959D construct [26]) into the pVAX1 vector (Invitrogen, Carlsbad … |
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By the time clinical symptoms of Alzheimer's disease (AD) manifest in patients there is already substantial tau pathology in the brain. Recent evidence also suggests that tau pathology can become self-propagating， further accelerating disease progression. Over the last decade several groups have tested the efficacy of protein-based anti-tau immunotherapeutics in various animal models of tauopathy. Here we report on the immunological and therapeutic potency of the first anti-tau DNA vaccine based on the MultiTEP platform， AV-1980D， in THY-Tau22 transgenic mice.
By the time clinical symptoms of Alzheimer's disease (AD) manifest in patients there is already substantial tau pathology in the brain. Recent evidence also suggests that tau pathology can become self-propagating， further accelerating disease progression. Over the last decade several groups have tested the efficacy of protein-based anti-tau immunotherapeutics in various animal models of tauopathy. Here we report on the immunological and therapeutic potency of the first anti-tau DNA vaccine based on the MultiTEP platform， AV-1980D， in THY-Tau22 transgenic mice.
Alzheimer’s diseases，Anti-tau antibody，DNA epitope vaccine，Tau immunotherapy，Transgenic
