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Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling

Journal of controlled release. 2024-10; 
Xing-Yue He , Meng-Meng Han , Yu-Chen Zhao , Ling Tang , Yi Wang , Lei Xing , Ning Wei , Jing Wang , Guang-Ji Wang , Fang Zhou, Jee-Heon Jeong, Hu-Lin Jiang
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Recombinant Proteins VEGF was from GenScript (Nanjing, China) Get A Quote

摘要

In the development of asthma, subepithelial fibrosis and vascular proliferation cause airway remodeling and narrowing, leading to disease deterioration and respiratory failure. In the clinic, the treatment of asthma was aimed at reducing the frequency of acute asthma attacks through inhaled corticosteroids (ICSs). However, ICSs cannot prevent the progression into refractory asthma due to the formation of airway remodeling mainly by subepithelial fibrosis and angiogenesis surrounding the tracheal lumen. Herein, we constructed surface-engineered mesenchymal stem cells (MSCs/PVLA) via the bioconjugation of MSCs and reactive oxygen species-responsive polymeric micelles loaded with vactosertib (VST) and linifanib (L... More

關鍵詞

Airway remodeling; Angiogenesis; Asthma; Mesenchymal stem cell; Subepithelial fibrosis
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