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Chimeric Porcine Parvovirus VP2 Virus-like Particles with Epitopes of South African Serotype 2 Foot-and-Mouth Disease Virus Elicits Specific Humoral and Cellular Responses in Mice

Viruses. 2024-04; 
Qian Li, Xusheng Ma, Yaner Shen, Junfei Dai, Xiaofeng Nian, Xiaofen Shang, Jiao Chen, Ashenafi Kiros Wubshet, Jie Zhang, Haixue Zheng
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Gene Synthesis … The M13F/R primers (Table 1) were used to PCR amplify the recombinant genes in the positive clones, … The corresponding genes were synthesized and sequenced by GenScript. The … Get A Quote

摘要

Southern Africa Territories 2 (SAT2) foot-and-mouth disease (FMD) has crossed long-standing regional boundaries in recent years and entered the Middle East. However, the existing vaccines offer poor cross-protection against the circulating strains in the field. Therefore, there is an urgent need for an alternative design approach for vaccines in anticipation of a pandemic of SAT2 Foot-and-mouth disease virus (FMDV). The porcine parvovirus (PPV) VP2 protein can embed exogenous epitopes into the four loops on its surface, assemble into virus-like particles (VLPs), and induce antibodies and cytokines to PPV and the exogenous epitope. In this study, chimeric porcine parvovirus VP2 VLPs (chimeric PPV-SAT2-VLPs) expr... More

關鍵詞

Epitope, FMDV, PPV, SAT2 serotype, chimeric VLP
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