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High expression of PPP1CC promotes NHEJ-mediated DNA repair leading to radioresistance and poor prognosis in nasopharyngeal carcinoma

Cell Death Differ. 2024-04; 
Ping Feng, Ying Wang, Na Liu, Yanming Chen, Yujun Hu, Zilu Huang, Ya Liu, Shuohan Zheng, Tongchao Jiang, Xiang Xiao, Wei Dai, Peng Huang, Yunfei Xia
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Proteins, Expression, Isolation and Analysis … (Millipore, USA) using sodium dodecyl sulfate?polyacrylamide gel electrophoresis (GenScript, USA). Then, 5% (w/v) bovine serum albumin (Sigma?Aldrich, USA) was used to block the … Get A Quote

摘要

Protein phosphatase 1 catalytic subunit gamma (PPP1CC) promotes DNA repair and tumor development and progression, however, its underlying mechanisms remain unclear. This study investigated the molecular mechanism of PPP1CC's involvement in DNA repair and the potential clinical implications. High expression of PPP1CC was significantly correlated with radioresistance and poor prognosis in human nasopharyngeal carcinoma (NPC) patients. The mechanistic study revealed that PPP1CC bound to Ku70/Ku80 heterodimers and activated DNA-PKcs by promoting DNA-PK holoenzyme formation, which enhanced nonhomologous end junction (NHEJ) -mediated DNA repair and led to radioresistance. Importantly, BRCA1-BRCA2-containing complex s... More

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