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Blocking the E2F transcription factor 1/high-mobility group box 2 pathway enhances the intervention effects of α-santalol on the malignant behaviors of liver cancer cells

Int J Biochem Cell Biol. 2024-01; 
Hui Wang, Min Tang, Erli Pei, Ying Shen, Aili Wang, Moubin Lin
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Proteins, Expression, Isolation and Analysis … proteins were extracted and then quantified using BCA kits (Thermo Scientific, USA). To obtain proteins … Gels (GenScript, China) to separate approximately 20 μg proteins from different … Get A Quote

摘要

In view of the tumor-inhibiting effect of α-santalol in various cancers and the role of E2F transcription factor 1 (E2F1) as an important target for anticancer research, this study investigates the relation between α-santalol and E2F1, as well as the effect of α-santalol on liver cancer progression and the corresponding mechanism. Concretely, liver cancer cells were treated with different concentrations of α-santalol. The IC value of α-santalol was determined using Probit regression analysis. Then, transcription factors that are targeted by α-santalol and differentially expressed in liver cancer were screened out. The clinicopathological impact of E2F1 and its targets were evaluated and predicted. The exp... More

關(guān)鍵詞

E2F transcription factor 1, High-mobility group box 2, Invasion, Liver cancer cells, Migration, Proliferation, α-Santalol
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