資源 » 參考數(shù)據(jù)庫 » 客戶發(fā)表文獻(xiàn)
Products/Services Used | Details | Operation |
---|---|---|
Proteins, Expression, Isolation and Analysis> | … The proteins (20 μg) were separated using 10% sodium dodecyl sulfate–polyacrylamide gel electrophoresis (Genscript, China) and then transferred to a polyvinyl difluoride membrane (… | Get A Quote |
background: The molecular targets and associated mechanisms of hepatocellular carcinoma (HCC) have been widely studied, but the roles of PDZK1 in HCC are unclear. Therefore, the aim of this study is to explore the role and associated mechanisms of PDZK1 in HCC. results: It was found that the expression of PDZK1 in HCC tissues was higher than that in paired paracancerous tissues. High expression of PDZK1 was associated with lymph node metastasis, degree of differentiation, and clinical stage. Upregulation of PDZK1 in HCC cells affected their proliferation, migration, invasion, apoptosis, and cell cycle, and also induced PI3K/AKT activation. PDZK1 is a downstream target gene of miR-101-3p. Accordingly, increase i... More