Products/Services Used | Details | Operation |
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Recombinant Proteins> | … All recombinant proteins were purchased from PeproTech (Rock Hill, NJ, USA) or Genscript (Nanjing, China). All cell culture products were obtained from Jet Biofil (Guangzhou, China) … | Get A Quote |
Leukemia stem cells (LSC) represent a crucial and rare subset of cells present in acute myeloid leukemia (AML); they play a pivotal role in the initiation, maintenance, and relapse of this disease. Targeting LSC holds great promise for preventing AML relapse and improving long-term outcomes. However the precise molecular mechanisms governing LSC self-renewal are still poorly understood. Here, we present compelling evidence that the expression of miR-30e-5p, a potential tumor-suppressive microRNA, is significantly lower in AML samples than in healthy bone marrow samples. Forced expression of miR- 30e effectively inhibits leukemogenesis, impairs LSC self-renewal, and delays leukemia progression. Mechanistically, ... More
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