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Myosin Va-dependent Transport of NMDA Receptors in Hippocampal Neurons

Neurosci Bull. 2024-01; 
Ru Gong, Linwei Qin, Linlin Chen, Ning Wang, Yifei Bao, Wei Lu
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Proteins, Expression, Isolation and Analysis … Equal amounts of total proteins from hippocampal slices or cells were mixed with glutathione resin (Genscript), together with either GST-MyoVa globular tails, medial tail sequence … Get A Quote

摘要

N-methyl-D-aspartate receptor (NMDAR) trafficking is a key process in the regulation of synaptic efficacy and brain function. However, the molecular mechanism underlying the surface transport of NMDARs is largely unknown. Here we identified myosin Va (MyoVa) as the specific motor protein that traffics NMDARs in hippocampal neurons. We found that MyoVa associates with NMDARs through its cargo binding domain. This association was increased during NMDAR surface transport. Knockdown of MyoVa suppressed NMDAR transport. We further demonstrated that Ca/calmodulin-dependent protein kinase II (CaMKII) regulates NMDAR transport through its direct interaction with MyoVa. Furthermore, MyoVa employed Rab11 family-interacti... More

關(guān)鍵詞

CaMKII, Memory, Myosin Va, NMDA receptor, Transport
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