資源 » 參考數(shù)據(jù)庫 » 客戶發(fā)表文獻
Products/Services Used | Details | Operation |
---|---|---|
Proteins, Expression, Isolation and Analysis> | … falciparum 230-kDa sexual-stage protein (Pfs230) [30] were produced in Lactococcus lactis, whereas P. falciparum circumsporozoite protein (PfCSP) was synthesized by Genscript. A … | Get A Quote |
Members of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are important targets for protective immunity. Abnormal display of PfEMP1 on the surfaces of infected erythrocytes (IEs) and reduced cytoadhesion have been demonstrated in hemoglobin (Hb) AS and HbAC, inherited blood disorders associated with protection against severe P. falciparum malaria. We found that Ghanaian children with HbAS had lower levels of immunoglobulin G against several PfEMP1 variants and that this reactivity increased more slowly with age than in their HbAA counterparts. Moreover, children with HbAS have lower total parasite biomass than those with HbAA at comparable peripheral parasitemias, suggesting impaired c... More