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Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients

Alzheimers Dement. 2023-12; 
Jean-Pierre Bellier, Yuqi Cai, Sarah M Alam, Thorsten Wiederhold, Arica Aiello, Jonathan S Vogelgsang, Sabina Berretta, Jasmeer P Chhatwal, Dennis J Selkoe, Lei Liu
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Proteins, Expression, Isolation and Analysis … Samples were loaded onto 4% to 12% Bis-Tris gels (SurePAGE, Genscript) using MES-SDS running buffer (Genscript), transferred to nitrocellulose membranes, and probed for various … Get A Quote

摘要

background: A wide array of post-translational modifications of the tau protein occurs in Alzheimer's disease (AD) and they are critical to pathogenesis and biomarker development. Several promising tau markers, pT181, pT217, and pT231, rely on increased phosphorylation within a common molecular motif threonine-proline-proline (TPP). methods: We validated new and existing antibodies against pT217, pT231, pT175, and pT181, then combined immunohistochemistry (IHC) and immunoassays (ELISA) to broadly examine the phosphorylation of the tau TPP motif in AD brains. results: The tau burden, as examined by IHC and ELISA, correlates to Braak stages across all TPP sites. Moreover, we observed regional variability across f... More

關(guān)鍵詞

Alzheimer's disease, brain, phosphorylation, tau protein
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