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RIF1 regulates early replication timing in murine B cells

Nat Commun. 2023-12; 
Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N Klein, Mariia Nazarova, Ursula E Schoeberl, David M Gilbert, Sara C B Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri
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Proteins, Expression, Isolation and Analysis … Cells were arrested with 100 ng ml ?1 α-factor (GenScript) for 2.5 h and protein expression was induced by the addition of 2% galactose for 2.5 h at 30 C. Cells were collected by … Get A Quote

摘要

The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating murine B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin and promotes early replication, but plays a minor role in regulating replication origin activity, gene expression and genome organization in B cells. Furthermore, we find that RIF1 functions in a complementary and non-epistatic manner with minichromosome maintenance (MCM) proteins to establish early RT signatures genome-wide and, specifi... More

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