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Ubiquitin-specific protease 22 promotes tumorigenesis and progression by an FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma

MedComm (2020). 2023-12; 
Qianwei Ye, Wei Zhou, Shengjun Xu, Qingyang Que, Qifan Zhan, Lincheng Zhang, Shusen Zheng, Sunbin Ling, Xiao Xu
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Proteins, Expression, Isolation and Analysis … Results: Usp22 accelerated c-Myc/NRasGV12 induced HCC in mice and mammalian target of … Proteins were separated by electrophoresis in 4–20% SDSPAGE gels (GenScript) and … Get A Quote

摘要

Ubiquitin-specific protease 22 (USP22) has been identified as a potential marker for cancer stem cells in hepatocellular carcinoma (HCC). It can promote HCC stemness, which is considered a driver of tumorigenesis. Here, we sought to determine the role of USP22 in tumorigenesis, elucidate its underlying mechanism, and explore its therapeutic significance in HCC. As a result, we found that tissue-specific Usp22 overexpression accelerated tumorigenesis, whereas Usp22 ablation decelerated it in a c-Myc/NRasGV12-induced HCC mouse model and that the mammalian target of rapamycin complex 1 (mTORC1) pathway was activated downstream. USP22 overexpression resulted in increased tumorigenic properties that were reversed by... More

關鍵詞

FK506‐binding protein 12 (FKBP12), autophagy, hepatocellular carcinoma (HCC), mammalian target of rapamycin complex 1 (mTORC1), tumorigenesis, ubiquitin‐specific protease 22 (USP22)
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