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m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma

J Biol Chem. 2023-05; 
Wei-Hong Zheng, Zhi-Qing Long, Zi-Qi Zheng, Lu-Lu Zhang, Ye-Lin Liang, Zhi-Xuan Li, Jia-Wei Lv, Jia Kou, Xiao-Hong Hong, Shi-Wei He, Rui Xu, Guan-Qun Zhou, Na Liu, Jun Ma, Ying Sun, Li Lin, Denghui Wei
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Proteins, Expression, Isolation and Analysis … In addition, we detected the expression level of LINC00839 in … LINC00839 were synthesized by Genscript and cloned into … of LINC00839 were synthesized by Genscript and cloned into … Get A Quote

摘要

Dysregulation of long noncoding RNAs (lncRNAs) contributes to tumorigenesis by modulating specific cancer-related pathways, but the roles of N6-methyladenosine (m6A)-enriched lncRNAs and underlying mechanisms remain elusive in nasopharyngeal carcinoma (NPC). Here, we reanalyzed the previous genome-wide analysis of lncRNA profiles in 18 pairs of NPC and normal tissues as well as in ten paired samples from NPC with or without post-treatment metastases. We discerned that an oncogenic m6A-enriched lncRNA, LINC00839, which was substantially upregulated in NPC and correlated with poor clinical prognosis, promoted NPC growth and metastasis both in?vitro and in?vivo. Mechanistically, by using RNA pull-down assay comb... More

關(guān)鍵詞

LINC00839, TAF15, m6A, nasopharyngeal carcinoma, progression
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