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Novel csuC-DNA nanovaccine based on chitosan candidate vaccine against infection with Acinetobacter baumannii

Vaccine. 2023-02; 
Eskandar Hosseinnezhad-Lazarjani, Abbas Doosti, Ali Sharifzadeh
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Proteins, Expression, Isolation and Analysis … Optimum Antigen Design Tool, a piece of bioinformatics software, was used … (GenScript, China). The secondary structure, surface availability, solubility in water, flexibility, and antigenic … Get A Quote

摘要

background: Generating vaccines is a promising and effective method for stopping the spread of Acinetobacter baumannii (A. baumannii) infections that are becoming more and more drug-resistant (MDR). Developing a DNA vaccine and testing its efficacy and protective effects in BALB/c mice were the goals of this research. methods: We examined the genomes of 35 different strains of A. baumannii using the Vaxign online program, and we selected outer membrane and secreted proteins as potential vaccine candidates. Next, the proteins' immunogenicity, antigenic features, physical and chemical characteristics, and B and MHCI/II cell epitope concentrations were assessed. The DNA vaccine was synthesized. Then, to generate C... More

關鍵詞

A. baumannii, Chitosan, DNA vaccine, Polymeric nanoparticles
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