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Trends in the evolution of the elasmobranch melanocortin-2 receptor: Insights from structure/function studies on the activation of whale shark Mc2r

Gen Comp Endocrinol. 2023-03; 
Brianne E Hoglin, Marin V Miner, Ugumuur Erbenebayar, Ciaran A Shaughnessy, Robert M Dores
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Proteins, Expression, Isolation and Analysis … All melanocortin-related cDNAs used in this project were synthesized by GenScript (Piscataway, NJ) and were individually inserted into a pcDNA3.1 + expression vector. The cDNAs … Get A Quote

摘要

To understand the mechanism for activation of the melanocortin-2 receptor (Mc2r) of the elasmobranch, Rhincodon typus (whale shark; ws), wsmc2r was co-expressed with wsmrap1 in CHO cells, and the transfected cells were stimulated with alanine-substituted analogs of ACTH(1-24) at the "message" motif (HFRW) and the "address" motif (KKRRP). Complete alanine substitution of the HFRW motif blocked activation, whereas single alanine substitution at this motif indicated the following hierarchy of position importance for activation: W?>?R, and substitution at F and H had no effect on activation. The same analysis was done on a representative bony vertebrate Mc2r ortholog (Amia calva; bowfin; bf) and the order of posi... More

關鍵詞

ACTH, Elasmobranch, Evolution, Melanocortin-2 receptor, Mrap1, Whale shark
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