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Cofilin 2 Acts as an Inflammatory Linker Between Chronic Periodontitis and Alzheimer's Disease in Amyloid Precursor Protein/Presenilin 1 Mice

Front Mol Neurosci. 2021-09; 
Qing Zeng, Qin Fang, Xincai Zhou, Hongfa Yang, Yang Dou, Wenhao Zhang, Pu Gong, Xianfang Rong
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摘要

Increasing evidence has shown a correlation between chronic periodontitis (CP) and Alzheimer's disease (AD). Nevertheless, there is still a lack of direct evidence, and especially key molecules to connect the two diseases. This study aims to investigate potential protein links between CP and AD within the inflammatory aspect. The hippocampus of CP model mice and controls were collected, and changes in protein expression were evaluated using two-dimensional differential in-gel electrophoresis (2D-DIGE) analysis combined with liquid chromatography tandem mass spectrometry. A total of 15 differentially expressed proteins were identified in CP model mice, as compared with the controls. Among them, S100-A9, transthy... More

關鍵詞

2D-DIGE, Alzheimer’s disease, Cofilin 2, chronic periodontitis, neuroinflammation
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