国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains

Cell Chem Biol. 2021-05; 
Teiko Komori Nomura, Kazuki Heishima, Nobuhiko Sugito, Ryota Sugawara, Hiroshi Ueda, Akao Yukihiro, Ryo Honda
Products/Services Used Details Operation
Endotoxin Detection & Removal System … of protein, as judged by ToxinSensor Chromogenic LAL Endotoxin Assay Kit (GenScript #L00350C). Prior to use, the protein was reconstituted by adding deionized water and passed … Get A Quote

摘要

Oncogenic RAS proteins, common oncogenic drivers in many human cancers, have been refractory to conventional small-molecule and macromolecule inhibitors due to their intracellular localization and the lack of druggable pockets. Here, we present a feasible strategy for designing RAS inhibitors that involves intracellular delivery of RAS-binding domain (RBD), a nanomolar-affinity specific ligand of RAS. Screening of 51 different combinations of RBD and cell-permeable peptides has identified Pen-cRaf-v1 as a cell-permeable pan-RAS inhibitor capable of targeting both G12C and non-G12C RAS mutants. Pen-cRaf-v1 crosses the cell membrane via endocytosis, competitively inhibits RAS-effector interaction, and thereby exe... More

關鍵詞

RAS, RAS-binding domain, cell-permeable peptides, fusion protein, molecular-targeted therapy, oncology, protein transduction, protein-protein interaction inhibitor, undruggable target
              主站蜘蛛池模板: 富顺县| 兴业县| 吴旗县| 科技| 岳西县| 邵阳县| 邹城市| 从化市| 建德市| 凌海市| 崇州市| 桓仁| 上犹县| 蒲江县| 乌鲁木齐市| 潮安县| 中江县| 眉山市| 美姑县| 连山| 丹东市| 锡林浩特市| 吴江市| 鄂尔多斯市| 宁化县| 明溪县| 武乡县| 中卫市| 河南省| 汪清县| 五台县| 湖南省| 太湖县| 会东县| 辽阳市| 通州市| 高密市| 洛阳市| 尉氏县| 逊克县| 渑池县|